The clinical implications of endothelial dysfunction. J Am Coll Cardiol 2003 Oct 01;42(7):1149-60
Date
10/03/2003Pubmed ID
14522472DOI
10.1016/s0735-1097(03)00994-xScopus ID
2-s2.0-0141504305 (requires institutional sign-in at Scopus site) 1363 CitationsAbstract
Defining new approaches for the prevention and treatment of atherosclerosis is an important priority. Recently, measurement of endothelial function in patients has emerged as a useful tool for atherosclerosis research. Risk factors are associated with impaired endothelial function, and clinical syndromes relate, in part, to a loss of endothelial control of vascular homeostasis. Recent studies have shown that the severity of endothelial dysfunction relates to cardiovascular risk. A growing number of interventions known to reduce cardiovascular risk have been shown to improve endothelial function. This work suggests that studies of endothelial function could be used in the care of patients and as a surrogate marker for the evaluation of new therapeutic strategies. This article will review this growing literature in an effort to evaluate the current clinical utility of endothelial dysfunction.
Author List
Widlansky ME, Gokce N, Keaney JF Jr, Vita JAAuthor
Michael E. Widlansky MD Associate Director, Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
ArteriosclerosisBiomarkers
Diagnostic Techniques, Cardiovascular
Endothelium, Vascular
Humans
