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The clinical implications of endothelial dysfunction. J Am Coll Cardiol 2003 Oct 01;42(7):1149-60

Date

10/03/2003

Pubmed ID

14522472

DOI

10.1016/s0735-1097(03)00994-x

Scopus ID

2-s2.0-0141504305   1126 Citations

Abstract

Defining new approaches for the prevention and treatment of atherosclerosis is an important priority. Recently, measurement of endothelial function in patients has emerged as a useful tool for atherosclerosis research. Risk factors are associated with impaired endothelial function, and clinical syndromes relate, in part, to a loss of endothelial control of vascular homeostasis. Recent studies have shown that the severity of endothelial dysfunction relates to cardiovascular risk. A growing number of interventions known to reduce cardiovascular risk have been shown to improve endothelial function. This work suggests that studies of endothelial function could be used in the care of patients and as a surrogate marker for the evaluation of new therapeutic strategies. This article will review this growing literature in an effort to evaluate the current clinical utility of endothelial dysfunction.

Author List

Widlansky ME, Gokce N, Keaney JF Jr, Vita JA

Author

Michael E. Widlansky MD Associate Director, Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Arteriosclerosis
Biomarkers
Diagnostic Techniques, Cardiovascular
Endothelium, Vascular
Humans
jenkins-FCD Prod-484 8aa07fc50b7f6d102f3dda2f4c7056ff84294d1d