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Effects of intestinal transplantation on postprandial motility and regulation of intestinal transit. Surgery 2001 Jan;129(1):6-14

Date

01/10/2001

Pubmed ID

11150028

DOI

10.1067/msy.2001.108612

Scopus ID

2-s2.0-0035143453   9 Citations

Abstract

BACKGROUND: The effects of intestinal transplantation on gut motility have not been completely defined. In this study we examine the effects of ileal transplantation on ileal smooth muscle contractility, together with gastroduodenal emptying, intestinal flow, and transit rates in a canine model of short-gut syndrome.

METHODS: Animals (n = 22) were instrumented with strain gauge transducers, collection cannulae, and infusion catheters to assess motility, intestinal flow and transit rates, and gastroduodenal emptying. Ten animals served to define normal parameters. Six animals underwent a 70% resection of the proximal small intestine to serve as short-gut controls. Six animals underwent removal of a 100-cm segment of the ileum, with cold storage, and autotransplantation the following day combined with a 70% resection of proximal bowel.

RESULTS: Transplant animals exhibited delayed gastroduodenal emptying, reduced intestinal flow rates, and postprandial phasic contractions that were similar to short-gut controls. However, transplant animals experienced rapid intestinal transit compared with short-gut controls (4.8 +/- 0.4 cm/min vs 2.0 +/- 0.3 cm/min; mean +/- SEM; P <.05).

CONCLUSIONS: The transplanted intestine, even with 18 hours of cold storage, exhibits a relatively normal postprandial motor response. However, adaptive responses of the transplanted intestine, such as regulation of intestine transit, may be impaired by neuromuscular injury associated with denervation or ischemia.

Author List

Johnson CP, Sarna SK, Zhu YR, Buchmann E, Bonham L, Telford GL, Roza AM, Adams MB

Authors

Christopher P. Johnson MD Professor in the Surgery department at Medical College of Wisconsin
Allan M. Roza MD Professor in the Surgery department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Disease Models, Animal
Dogs
Eating
Fasting
Female
Gastrointestinal Motility
Humans
Ileum
Male
Muscle Contraction
Short Bowel Syndrome
Transplantation, Autologous
jenkins-FCD Prod-478 d1509cf07a111124a2d122fd3df854cc0b993c00