Faculty Collaboration Database

Body mass index, cognition, disability, APOE genotype, and mortality: the "Treviso Longeva" Study. Am J Geriatr Psychiatry 2012 Jul;20(7):594-602

Date

10/13/2011

Pubmed ID

21989319

DOI

10.1097/JGP.0b013e31823031a4

Scopus ID

2-s2.0-84863515925 (requires institutional sign-in at Scopus site)   21 Citations

Abstract

OBJECTIVES: The concurrent contributions of dynamic, interrelated late-life parameters, such as body mass index (BMI), cognition, and physical functioning on mortality in the elderly are unclear, as is the influence of APOE genotype. We explored these measures in relation to 7-year mortality in long-lived Italian elderly.

DESIGN: A representative, age-stratified, population sample.

SETTING: The Treviso Longeva (TRELONG) Study, in Treviso, Italy.

PARTICIPANTS: Three hundred eleven men and 357 women, aged 70 years and older (mean age 84 ± 8 years).

MEASUREMENTS: Seven-year mortality, BMI, Mini-Mental State Examination (MMSE) score, Activities of Daily Living (ADL), APOE genotype, and a variety of clinical and survey data.

RESULTS: In separate age- and sex-adjusted analyses, BMI <18.5 kg/m(2), MMSE ≤24, and ADL <6, were associated with greater 7-year mortality among adults aged 70 years and older. In a multivariate model including all factors, MMSE ≤24, and ADL <6 were associated with greater mortality; BMI ≥30 kg/m(2) was protective. There were no interactions between BMI, MMSE, or ADL. When excluding those dying within 3 years of baseline, only an MMSE ≤24 was related to mortality. APOEε4 was not related to mortality.

CONCLUSION: Higher MMSE score, higher ADL score, and higher BMI, independent of age, sex, and other factors, are markers for longer life among northern Italian adults aged 70 years or older. Global cognition, BMI, and physical functioning, assessed by short, simple tests are profound indicators of death within less than a decade.

Author List

Gustafson DR, Mazzuco S, Ongaro F, Antuono P, Forloni G, Albani D, Gajo GB, Durante E, Caberlotto L, Zanardo A, Siculi M, Gallucci M

Author

Piero G. Antuono MD Professor in the Neurology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Activities of Daily Living
Aged
Aged, 80 and over
Aging
Apolipoproteins E
Body Mass Index
Cognition
Disability Evaluation
Female
Genotype
Humans
Male
Mortality
Neuropsychological Tests