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ddAVP does not stimulate acute changes in levels of medullary trimethylamines in humans. J Am Soc Nephrol 1993 Dec;4(6):1379-84

Date

12/01/1993

Pubmed ID

8130365

DOI

10.1681/ASN.V461379

Scopus ID

2-s2.0-0027727730

Abstract

1H nuclear magnetic resonance has been used to determine the effect of acute iv administration of the arginine vasopressin analog 1-(3-mercaptopropionic acid)-8-D-arginine vasopressin monoacetate (ddAVP; 2 micrograms) on renal medullary trimethylamine (TMA) levels in human volunteers. In subjects deprived of food and water for 15 h, urine osmolality (Uosm) was 889 +/- 47 mosmol/kg and had not changed significantly 3 h after ddAVP administration. Medullary TMA did not change significantly over 3 h after ddAVP. In a second group of subjects who were well hydrated, acute ddAVP infusion increased Uosm from 203 +/- 63 to 421 +/- 47 mosmol/kg in 3 h (P < 0.05). However, medullary TMA did not change significantly over this time period. These results indicate that ddAVP, and presumably arginine vasopressin, do not acutely influence medullary TMA levels, and they support the view that results previously reported for animal and isolated cell systems are also applicable to human physiology.

Author List

Avison MJ, Van Why SK, Siegel NJ

Author

Scott K. Van Why MD Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adult
Deamino Arginine Vasopressin
Humans
Injections, Intravenous
Kidney Medulla
Magnetic Resonance Spectroscopy
Methylamines
Osmolar Concentration
Urine
Water-Electrolyte Balance