Noninvasive assessment of neoplastic angiogenesis: the role of magnetic resonance imaging. Semin Thromb Hemost 2003 Jun;29(3):309-15
Date
07/31/2003Pubmed ID
12888935DOI
10.1055/s-2003-40969Scopus ID
2-s2.0-0038095537 (requires institutional sign-in at Scopus site) 6 CitationsAbstract
The study of the effect of angiogenesis inhibitors on tumors is limited by our ability to assess their effect in vivo. Approaches that are currently employed have significant limitations. An ideal approach would employ a widely available noninvasive technology that can be used repeatedly to assess the antiangiogenic effect on the same lesions in a serial fashion. We describe here a specialized magnetic resonance imaging (MRI)-based technique that we employ in the study of angiogenesis of brain tumors. This technique, called relative cerebral blood volume (rCBV) mapping, is a noninvasive technique that adds just a few minutes to the conventional MRI study of a human brain tumor in the clinical setting. We hope that such a technique will serve as a model for developing new imaging techniques for the assessment of angiogenesis modulation in other tumor settings. We describe the technical basis and some examples of using rCBV mapping in neoplastic angiogenesis assessment, including a discussion of current limitations and future directions.
Author List
Abu-Hajir M, Rand SD, Krouwer HG, Schmainda KMAuthor
Kathleen M. Schmainda PhD Professor in the Biophysics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Brain NeoplasmsHumans
Magnetic Resonance Imaging
Neovascularization, Pathologic
