Pseudo-reorganization of language cortical function at fMR imaging: a consequence of tumor-induced neurovascular uncoupling. AJNR Am J Neuroradiol 2003 Feb;24(2):213-7
Date
02/20/2003Pubmed ID
12591636Pubmed Central ID
PMC7974126Scopus ID
2-s2.0-0037328695 (requires institutional sign-in at Scopus site) 117 CitationsAbstract
A left-handed patient with a grade II left frontal lobe astrocytoma had spontaneous seizures causing speech arrest and uncontrolled right upper extremity movements. Word-generation functional MR (fMR) imaging showed activity nearly exclusively in the right inferior frontal gyrus. The clinical history of the speech arrest and the intraoperative mapping proved left-hemisphere language dominance. Tumor involvement of the left inferior frontal gyrus caused uncoupling of the blood oxygenation level-dependent (BOLD) and neuronal response, leading to the erroneous fMR imaging appearance of right-hemisphere language dominance. Discrepancies between BOLD and intraoperative mapping in areas near lesions illustrate the complementary nature of these techniques.
Author List
Ulmer JL, Krouwer HG, Mueller WM, Ugurel MS, Kocak M, Mark LPAuthor
Wade M. Mueller MD Professor in the Neurosurgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAphasia, Broca
Astrocytoma
Brain Mapping
Brain Neoplasms
Diagnosis, Differential
Dominance, Cerebral
Echo-Planar Imaging
Frontal Lobe
Humans
Image Processing, Computer-Assisted
Imaging, Three-Dimensional
Magnetic Resonance Imaging
Male
Nerve Regeneration
Neuronal Plasticity
Neurons
Oxygen Consumption
Regional Blood Flow
Sensitivity and Specificity
