Faculty Collaboration Database

ATP-sensitive potassium channels in rat primary afferent neurons: the effect of neuropathic injury and gabapentin. Neurosci Lett 2003 Jun 12;343(3):185-9

Date

05/29/2003

Pubmed ID

12770693

DOI

10.1016/s0304-3940(03)00383-5

Scopus ID

2-s2.0-0038548409 (requires institutional sign-in at Scopus site)   39 Citations

Abstract

ATP-sensitive potassium (K(ATP)) currents were examined in dorsal root ganglion neurons from neuropathic and control rats using whole-cell voltage clamp recordings. K(ATP) channel openers (diazoxide and pinacidil) enhanced, and the blocker glibenclamide inhibited an outward current in control neurons in a manner dependent on the pipette ATP concentration. Analysis of reversal potentials showed that this current is carried by K(+) ions. Outward current in cells from rats with peripheral nerve injury was not sensitive to modulators of K(ATP) channels. Gabapentin, a putative K(ATP) channel opener, had minimal effect on currents in either group of neurons. We conclude that normal primary afferent neurons express K(ATP) channels that conduct current which is eliminated by peripheral nerve injury. Gabapentin does not affect this current significantly.

Author List

Sarantopoulos C, McCallum B, Sapunar D, Kwok WM, Hogan Q

Author

Wai-Meng Kwok PhD Professor in the Anesthesiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

ATP-Binding Cassette Transporters
Acetates
Amines
Animals
Basal Ganglia
Cyclohexanecarboxylic Acids
Diazoxide
Excitatory Amino Acid Antagonists
Ganglia, Spinal
Glyburide
KATP Channels
Male
Neurons, Afferent
Neuroprotective Agents
Pain
Peripheral Nervous System Diseases
Pinacidil
Potassium Channel Blockers
Potassium Channels
Potassium Channels, Inwardly Rectifying
Rats
Rats, Sprague-Dawley
gamma-Aminobutyric Acid