Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Comparative evaluation of a new immunoradiometric assay for corticotropin. Clin Chem Lab Med 2006;44(5):669-71



Pubmed ID




Scopus ID

2-s2.0-33646699125   14 Citations


We have characterized the performance of a commercial two-site immunoradiometric assay for manual in vitro diagnostic measurement of plasma corticotropin from Scantibodies Laboratory. We compared the results with those of a similar commonly used assay from Nichols Institute Diagnostics that has recently been withdrawn from production. The lower detection limit, range of the standard curve, cross-reactivity, and intra-assay and inter-assay imprecision of the two assays are very similar. Measurement of clinical samples and a series of samples from an experimental subject demonstrate high correlations between the two assays. These factors, together with recent clearance by the United States Food and Drug Administration for manual in vitro diagnostic measurement, make the Scantibodies corticotropin immunoradiometric assay an appropriate replacement for the Nichols assay.

Author List

Wilkinson CW, Raff H


Hershel Raff PhD Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adrenocorticotropic Hormone
Chemistry, Clinical
Dose-Response Relationship, Drug
Evaluation Studies as Topic
Immunoradiometric Assay
Regression Analysis
Reproducibility of Results
Sensitivity and Specificity
Time Factors
jenkins-FCD Prod-484 8aa07fc50b7f6d102f3dda2f4c7056ff84294d1d