Vesiculopustular eruptions in Down syndrome neonates with myeloproliferative disorders. Arch Dermatol 2001 Jun;137(6):760-3
Date
06/19/2001Pubmed ID
11405767Scopus ID
2-s2.0-0034972222 (requires institutional sign-in at Scopus site) 36 CitationsAbstract
BACKGROUND: Infants with Down syndrome are at increased risk for hematologic abnormalities, including leukemoid reaction, transient myeloproliferative disorder, and congenital leukemia. The differential diagnosis of a vesiculopustular eruption in an infant with Down syndrome and these hematologic abnormalities is broad and includes benign, self-limited disorders as well as life-threatening infections.
OBSERVATION: We describe 3 newborns with Down syndrome and vesiculopustular eruptions associated with myeloproliferative disorders during the neonatal period. These lesions differ from other neonatal vesicular eruptions in that they have a unique distribution, display pathergy, and contain immature hematopoietic cells similar to circulating blast cells. Resolution occurs without treatment as the hematologic disorder subsides.
CONCLUSIONS: Infants with Down syndrome and hematologic abnormalities may have a cutaneous eruption that has characteristic clinical and histopathologic findings. It is possible that this eruption has been unrecognized in the past because of its self-limited course. Whether this eruption is a prognostic factor for the subsequent development of leukemia is uncertain.
Author List
Nijhawan A, Baselga E, Gonzalez-Ensenat MA, Vicente A, Southern JF, Camitta BM, Esterly NB, Drolet BAMESH terms used to index this publication - Major topics in bold
Diagnosis, DifferentialDown Syndrome
Facial Dermatoses
Fatal Outcome
Female
Humans
Infant, Newborn
Leukemia, Myeloid, Acute
Male
Skin Diseases, Vesiculobullous
