Faculty Collaboration Database

Effect of treatment on quality of life among men with clinically localized prostate cancer. Med Care 2001 Mar;39(3):243-53

Date

03/10/2001

Pubmed ID

11242319

DOI

10.1097/00005650-200103000-00005

Scopus ID

2-s2.0-0035286716 (requires institutional sign-in at Scopus site)   80 Citations

Abstract

BACKGROUND: Quality-of-life outcomes are an important consideration for patients evaluating therapeutic options for localized prostate cancer.

OBJECTIVES: The objective of this study was to describe the effect of treatment choice on change in health-related quality of life (HRQOL) among men with clinically localized prostate cancer.

RESEARCH DESIGN: This was a prospective observational study.

SUBJECTS: The study subjects were 122 men with clinically localized adenocarcinoma of the prostate. Forty-two subjects (34%) underwent radical prostatectomy, 51 (42%) underwent radiation therapy, and 29 (24%) were followed with expectant management.

MEASURES: The University of California at Los Angeles Prostate Cancer Quality of Life Inde- and the Medical Outcomes Study Short Form-36 were administered before and 3 and 12 months after initial treatment. The study used an analysis of covariance model adjusted for baseline differences in clinical and demographic factors.

RESULTS: Men who underwent radical prostatectomy experienced significant declines in urinary and sexual function and bother that persisted at 12 months after treatment. Men treated with radiation therapy experienced smaller but significant declines in sexual function and a decline in social function. Expectant management patients did not have a significant change in disease-targeted or generic HRQOL domains. Differential rates of change in urinary and sexual function between treatment groups persisted after adjustment for differences in pretreatment clinical and demographic factors.

CONCLUSIONS: Men undergoing radical prostatectomy have substantial declines in urinary and sexual function, and men undergoing radiotherapy have declines in sexual function. Men undergoing expectant management have no change in disease-specific or general HRQOL in the first year after treatment.

Author List

Schapira MM, Lawrence WF, Katz DA, McAuliffe TL, Nattinger AB

Authors

Timothy L. McAuliffe PhD Professor in the Psychiatry and Behavioral Medicine department at Medical College of Wisconsin
Ann B. Nattinger MD, MPH Associate Provost, Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adenocarcinoma
Aged
Aged, 80 and over
Analysis of Variance
Erectile Dysfunction
Health Status
Health Status Indicators
Humans
Male
Middle Aged
Patient Selection
Prospective Studies
Prostatectomy
Prostatic Neoplasms
Quality of Life
Radiotherapy
Surveys and Questionnaires
Treatment Outcome
Urination Disorders
Wisconsin