Motoneuron injury and repair: New perspectives on gonadal steroids as neurotherapeutics. J Mol Neurosci 2006;28(1):53-64
Date
04/25/2006Pubmed ID
16632875DOI
10.1385/jmn:28:1:53Scopus ID
2-s2.0-33646873698 (requires institutional sign-in at Scopus site) 27 CitationsAbstract
In this review, we will summarize recent work from our laboratory on the role of gonadal steroids as neuroprotective agents in motoneuron viability following cell stress. Three motoneuron models will be discussed: developing axotomized hamster facial motoneurons (FMNs); adult axotomized mouse FMNs; and immortalized, cultured mouse spinal motoneurons subjected to heat shock. New work on two relevant motoneuron proteins, the survival of motor neuron protein, and neuritin or candidate plasticity-related gene 15, indicates differential steroid regulation of these two proteins after axotomy. The concept of gonadal steroids as cellular stress correction factors and the implications of this for acute neurological injury situations will be presented as well.
Author List
Tetzlaff JE, Huppenbauer CB, Tanzer L, Alexander TD, Jones KJAuthor
Julie Tetzlaff PhD Associate Professor in the Pathology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsAxotomy
Cell Survival
Cells, Cultured
Cyclic AMP Response Element-Binding Protein
Facial Nerve
GPI-Linked Proteins
Gonadal Steroid Hormones
Hot Temperature
Membrane Proteins
Motor Neurons
Nerve Regeneration
Nerve Tissue Proteins
Neuroprotective Agents
RNA-Binding Proteins
SMN Complex Proteins
