Impact of bone marrow hematogones on umbilical cord blood transplantation outcomes in patients with acute myeloid leukemia. Biol Blood Marrow Transplant 2012 Jun;18(6):930-6
Date
11/24/2011Pubmed ID
22108570Pubmed Central ID
PMC4378716DOI
10.1016/j.bbmt.2011.11.015Scopus ID
2-s2.0-84860835017 (requires institutional sign-in at Scopus site) 23 CitationsAbstract
Early after umbilical cord blood transplantation, patients show marked differences in bone marrow (BM) hematogone percentages. Little is known about whether these differences are clinically relevant. We hypothesized that early recovery of hematogones may be associated with improved transplantation outcomes. BM aspirates were assessed from 88 patients with acute myeloid leukemia by two independent reviewers at day 21 and 100 after umbilical cord blood transplantation. Interobserver variability for BM hematogone percentages at these time points showed correlation coefficients of 0.83 and 0.98, respectively (P ≤ .01 for both). A high percentage of hematogones at day 21 was associated with less acute graft-versus-host disease grade 3 to 4 (P = .01). At day 100, a high percentage of BM hematogones was associated with improved overall survival (P = .02) and lower treatment-related mortality (P ≤ .01). This study shows that BM hematogone percentages may be useful prognostic indicators in patients with acute myeloid leukemia after umbilical cord blood transplantation and should be routinely reported in BM differential counts.
Author List
Honebrink T, Dayton V, Burke MJ, Larsen K, Cao Q, Brunstein C, Weisdorf D, Miller JS, Wagner JE, Verneris MRAuthor
Michael James Burke MD Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Biomarkers
Bone Marrow Cells
Cell Count
Child
Child, Preschool
Cord Blood Stem Cell Transplantation
Female
Fetal Blood
Graft vs Host Disease
Humans
Immunophenotyping
Infant
Leukemia, Myeloid, Acute
Longitudinal Studies
Male
Observer Variation
Secondary Prevention
Severity of Illness Index
Survival Analysis
Treatment Outcome
