Neural events leading to and associated with detection of sounds under high processing load. Hum Brain Mapp 2013 Mar;34(3):587-97
Date
11/22/2011Pubmed ID
22102362Pubmed Central ID
PMC3297708DOI
10.1002/hbm.21457Scopus ID
2-s2.0-84873432629 (requires institutional sign-in at Scopus site) 6 CitationsAbstract
The neural events that lead to successful or failed detection of suprathreshold sounds are not well established. In this experiment, event-related potentials (ERPs) and functional magnetic resonance imaging (fMRI) were recorded while participants performed two tasks: a primary difficult duration judgment task on a sequence of tones presented to one ear, and a secondary target detection task on an auditory oddball stream presented to the other ear. The paradigm was designed to elicit competition and variability in detection of auditory targets despite identical input. Successful detection of auditory targets was associated mainly with greater fMRI activity in superior parietal cortex and thalamus. In the ERPs, successful detection was linked with a larger fronto-central negativity at 200-400 ms, and a later centro-posterior positivity. Failure to detect targets was associated with greater fMRI signal in the default mode network, a significantly smaller electrical fronto-central negativity and no late positivity. These findings demonstrate that variability in auditory detection is related to modulation of activity in multimodal parietal and frontal networks active ∼ 200 ms after target onset. Results are consistent with a limited capacity and late selection view of attention.
Author List
Sabri M, Humphries C, Binder JR, Liebenthal EAuthor
Jeffrey R. Binder MD Professor in the Neurology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Acoustic StimulationAdult
Auditory Perception
Brain Mapping
Cerebral Cortex
Electroencephalography
Evoked Potentials, Auditory
Female
Functional Laterality
Humans
Image Processing, Computer-Assisted
Judgment
Magnetic Resonance Imaging
Male
Nerve Net
Neuropsychological Tests
Oxygen
Signal Detection, Psychological
Sound
