Faculty Collaboration Database

Sedative, analgesic and cognitive effects of clonidine infusions in humans. Br J Anaesth 2001 Jan;86(1):5-11

Date

09/29/2001

Pubmed ID

11575409

DOI

10.1093/bja/86.1.5

Scopus ID

2-s2.0-0035179675 (requires institutional sign-in at Scopus site)   149 Citations

Abstract

This placebo-controlled, randomized study evaluated, on separate days, the dose-response relationship for 1 h infusions of clonidine 1, 2 and 4 microg kg(-1) h(-1), in eight healthy volunteers aged 22-30 yr. Response end-points included sedation (bispectral index, visual analogue scale and observer assessment of sedation), analgesia to a cold pressor test, memory (recall of word lists), cognitive function (digit symbol substitution test (DSST)), respiratory function (respiratory rate, end-tidal carbon dioxide, oxygen saturation) and haemodynamic stability (heart rate and mean arterial pressure). Clonidine infusions resulted in significant and progressive sedation, but all subjects were easily awoken to perform tests and evaluations. Statistically significant analgesia, memory impairment and reduced performance on the DSST occurred during 4 microg kg(-1) h(-1) infusions (resulting in a plasma concentration of 2 ng ml(-1). There were no statistically significant changes in cardiorespiratory variables throughout the study.

Author List

Hall JE, Uhrich TD, Ebert TJ

Author

Thomas J. Ebert MD, PhD Adjunct Professor in the Anesthesiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adrenergic alpha-Agonists
Adult
Analgesics
Clonidine
Cognition
Conscious Sedation
Dose-Response Relationship, Drug
Female
Hemodynamics
Humans
Hypnotics and Sedatives
Male
Mental Recall
Pain Measurement
Respiration