Faculty Collaboration Database

The relationship between insulin-like growth factor-I, adiposity, and aging. Metabolism 1990 Jun;39(6):584-7

Date

06/01/1990

Pubmed ID

2352477

DOI

10.1016/0026-0495(90)90022-5

Scopus ID

2-s2.0-0025347581 (requires institutional sign-in at Scopus site)   162 Citations

Abstract

Aging is associated with both a relative accumulation of body fat and a reduction in growth hormone (GH) secretion. This study was devised to investigate the relationship between plasma insulin-like growth factor-I (IGF-I), an index of GH secretion, and anthropometric indices of body fat in normal subjects of various ages. Somatic and biochemical indices of nutrition were assessed in 107 subjects between the ages of 17 and 83 years who attended an outpatient clinic for general health supervision. Plasma IGF-I correlated negatively with age in both males (r = -.44, P = .001) and females (r = -.40, P = .005). In addition, plasma IGF-I correlated negatively with body mass index (BMI) (r = .35, P = .006), percentage of standard triceps skinfold (TSF) (r = -.26, P = .05), and percentage of standard weight (r = -.35, P = .006) in males, but not in females. Multiple regression analysis indicated that in males, BMI and percentage of standard weight correlated with plasma IGF-I independent of the effect of age. We conclude that adiposity and aging are independently associated with decreased plasma IGF-I concentrations. The negative correlations between indices of adiposity and IGF-I were observed only in males, whereas the age-associated decline in IGF-I was present in both males and females. We speculate that sex differences in the gonadal steroid milieu, combined with declining GH secretion in both sexes, may contribute to the age-associated development of obesity in males.

Author List

Copeland KC, Colletti RB, Devlin JT, McAuliffe TL

Author

Timothy L. McAuliffe PhD Professor in the Psychiatry and Behavioral Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adipose Tissue
Adolescent
Adult
Aged
Aged, 80 and over
Aging
Anthropometry
Female
Humans
Insulin-Like Growth Factor I
Male
Middle Aged
Obesity
Osmolar Concentration
Regression Analysis
Sex Characteristics
Somatomedins