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RNP localization and transport in yeast. Annu Rev Cell Dev Biol 2001;17:297-310

Date

11/01/2001

Pubmed ID

11687491

DOI

10.1146/annurev.cellbio.17.1.297

Scopus ID

2-s2.0-0035184223   62 Citations

Abstract

The localization of mRNAs is used by various types of polarized cells to locally translate specific proteins, which restricts their distribution to a particular sub-region of the cytoplasm. This mechanism of protein sorting is involved in major biological processes such as asymmetric cell division, oogenesis, cellular motility, and synapse formation. With the finding of localized mRNAs in the yeast Saccharomyces cerevisiae, it is now possible to benefit from the powerful yeast laboratory tools to explore the molecular basis of RNA localization. Because mRNA transport and localization in yeast share many features with RNA localization in higher eukaryotes, including the formation of a large ribonucleoprotein (RNP) localization complex, the requirement of a polarized cytoskeleton and molecular motors, and the role of nuclear RNA-binding proteins in cytoplasmic localization, the yeast can be used as a paradigm for unraveling the molecular aspects of this process. This review summarizes the current knowledge on RNP transport and localization in yeast.

Author List

Chartrand P, Singer RH, Long RM

Author

Roy M. Long PhD Assistant Dean, Associate Professor in the Medical School Regional Campuses department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Actins
Biological Transport
Cytoskeletal Proteins
Models, Molecular
Protein Sorting Signals
RNA, Fungal
RNA, Messenger
Ribonucleoproteins
Saccharomyces cerevisiae