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A genomic-systems biology map for cardiovascular function. Science 2001 Nov 23;294(5547):1723-6

Date

11/27/2001

Pubmed ID

11721057

DOI

10.1126/science.1062117

Abstract

With the draft sequence of the human genome available, there is a need to better define gene function in the context of systems biology. We studied 239 cardiovascular and renal phenotypes in 113 male rats derived from an F2 intercross and mapped 81 of these traits onto the genome. Aggregates of traits were identified on chromosomes 1, 2, 7, and 18. Systems biology was assessed by examining patterns of correlations ("physiological profiles") that can be used for gene hunting, mechanism-based physiological studies, and, with comparative genomics, translating these data to the human genome.

Author List

Stoll M, Cowley AW Jr, Tonellato PJ, Greene AS, Kaldunski ML, Roman RJ, Dumas P, Schork NJ, Wang Z, Jacob HJ

Author

Allen W. Cowley Jr PhD Professor in the Physiology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Blood Pressure
Cardiovascular Physiological Phenomena
Chromosome Mapping
Chromosomes
Crosses, Genetic
Female
Genomics
Humans
Kidney
Lod Score
Male
Nitric Oxide Synthase
Norepinephrine
Phenotype
Quantitative Trait, Heritable
Rats
Vasodilation