Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Zollinger-Ellison syndrome associated with a history of alcohol abuse: coincidence or consequence? Surgery 2011 Dec;150(6):1129-35

Date

12/06/2011

Pubmed ID

22136832

DOI

10.1016/j.surg.2011.09.004

Scopus ID

2-s2.0-82755195095   6 Citations

Abstract

BACKGROUND: This 47-year observational study suggests that sporadic Zollinger-Ellison (Z-E) syndrome, particularly duodenal wall gastrinomas (DWG), is associated with a history of alcohol abuse.

METHODS: Thirty-nine consecutive Z-E patients were followed from 1962 through 2010. The drinking patterns of these patients were assessed and compared with 3,786 community controls.

RESULTS: Thirty-five patients had extrapancreatic gastrinomas (34 DWG and/or paraduodenal lymph nodes, 1 antral gastrinoma). Total gastrectomy was done in 24; 9 underwent less extensive operations to remove DWG, and 2 patients had no operations. There were no deaths from tumor progression. Four patients presented with pancreatic gastrinoma (PG) and liver metastasis, all died from tumor progression. Alcohol abuse (>50 g/d) was documented in 81% of patients with DWG and/or paraduodenal lymph nodes. The drinking patterns (drinks per day) of DWG patients were significantly different: DWG vs community control-abstainers, 3% vs 24%; 1-2 drinks, 16% vs 62%; 3-5 drinks, 29% vs 12%; and a?Y 6 drinks, 52% vs 2.5% (P < .01).

CONCLUSION: Alcohol abuse is strongly associated with and may be a risk factor for sporadic Z-E with extrapancreatic DWG. Liver metastases and tumor deaths were not observed in this subgroup, supporting the concept that DWG and PG are different tumor entities.

Author List

Wilson SD, Doffek KM, Krzywda EA, Quebbeman EJ, Christians KK, Pappas SG

Author

Kathleen K. Christians MD Professor in the Surgery department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adult
Aged
Alcohol-Related Disorders
Duodenal Neoplasms
Female
Gastrinoma
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Pancreatic Neoplasms
Risk Factors
Survival Rate
Zollinger-Ellison Syndrome