Discovery of 2-(2-benzoxazoyl amino)-4-aryl-5-cyanopyrimidine as negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGlu₅): from an artificial neural network virtual screen to an in vivo tool compound. ChemMedChem 2012 Mar 05;7(3):406-14
Date
01/24/2012Pubmed ID
22267125Pubmed Central ID
PMC3517057DOI
10.1002/cmdc.201100510Scopus ID
2-s2.0-84857732011 (requires institutional sign-in at Scopus site) 38 CitationsAuthor List
Mueller R, Dawson ES, Meiler J, Rodriguez AL, Chauder BA, Bates BS, Felts AS, Lamb JP, Menon UN, Jadhav SB, Kane AS, Jones CK, Gregory KJ, Niswender CM, Conn PJ, Olsen CM, Winder DG, Emmitte KA, Lindsley CWAuthor
Christopher M. Olsen PhD Associate Professor in the Pharmacology and Toxicology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Allosteric RegulationAnimals
Anxiety Disorders
Behavior, Animal
Benzoxazoles
Brain
Drug Discovery
Glutamic Acid
HEK293 Cells
High-Throughput Screening Assays
Humans
Injections, Intraperitoneal
Mice
Mice, Inbred C57BL
Psychotropic Drugs
Pyrimidines
ROC Curve
Receptor, Metabotropic Glutamate 5
Receptors, Metabotropic Glutamate
Small Molecule Libraries
