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14, 15-Epoxyeicosatrienoic acid promotes endothelial cell dependent adhesion of human monocytic tumor U937 cells. Biochem Biophys Res Commun 1990 Feb 28;167(1):137-42

Date

02/28/1990

Pubmed ID

2310385

DOI

10.1016/0006-291x(90)91741-a

Scopus ID

2-s2.0-0025253159   27 Citations

Abstract

Arachidonic acid (AA) can be metabolized in endothelial cells (EC) to a series of epoxides via cytochrome P-450 epoxygenase with 14,15 epoxyeicosatrienoic acid (14,15-EET) as the major product. In this communication we report that 14,15-EET significantly enhances U937 cell attachment to EC with maximal cell attachment at 2.5 to 5 x 10(-7) M 14,15-EET. Thus, 14,15-EET may play a substantial role in inflammation and/or atherogenesis by inducing monocyte attachment to EC.

Author List

Pritchard KA Jr, Tota RR, Stemerman MB, Wong PY

Author

Kirkwood A. Pritchard PhD Professor in the Surgery department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

8,11,14-Eicosatrienoic Acid
Cell Adhesion
Cells, Cultured
Chromatography, High Pressure Liquid
Endothelium
Fatty Acids, Unsaturated
Fluorescent Dyes
Humans
L-Lactate Dehydrogenase
Prostaglandins
Thrombin
Tumor Cells, Cultured
jenkins-FCD Prod-482 91ad8a360b6da540234915ea01ff80e38bfdb40a