Faculty Collaboration Database

The identification of different endothelial cell populations within the mouse proepicardium. Dev Dyn 2011 Oct;240(10):2344-53

Date

09/21/2011

Pubmed ID

21932312

Pubmed Central ID

PMC3275641

DOI

10.1002/dvdy.22724

Scopus ID

2-s2.0-80052964970 (requires institutional sign-in at Scopus site)   34 Citations

Abstract

The proepicardium is a transient embryonic structure that is a source of precursors of the epicardium, coronary smooth muscle cells, and may be a source of coronary endothelial cells (EC). To better understand proepicardium development a systematic analysis of EC appearance was performed. Multiple marker analysis showed that EC are present in the mouse proepicardium at embryonic day (E) 9.0 through E9.75. Distinct populations of EC were found that were associated with the liver bud, and the sinus venosus, as well as a population that do not appear to be associated with either of these structures. There was a temporal increase in the number of EC and temporal changes in the distribution of EC within the different populations during PE development. These findings indicate that EC exist in the proepicardium before coronary vasculogenesis, and support a model in which there is a heterogeneous origin for EC in the proepicardium.

Author List

Cossette S, Misra R

Author

Ravindra P. Misra PhD Associate Provost, Professor in the Biochemistry department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Biomarkers
Embryo, Mammalian
Endothelial Cells
Female
Heart
Mice
Morphogenesis
Pericardium
Platelet Endothelial Cell Adhesion Molecule-1