Presence of simian virus 40 DNA sequences in human lymphomas. Lancet 2002 Mar 09;359(9309):851-2
Date
03/19/2002Pubmed ID
11897287DOI
10.1016/S0140-6736(02)07921-7Scopus ID
2-s2.0-0037045832 (requires institutional sign-in at Scopus site) 140 CitationsAbstract
Simian virus 40 (SV40)--a potent oncogenic virus--has been associated previously with some types of human tumours, but not with lymphomas. We examined human tumours for the presence of specific SV40 DNA sequences by PCR and Southern blotting. Viral sequences were present in 29 (43%) of 68 non-Hodgkin lymphomas, and in three (9%) of 31 of Hodgkin's lymphomas. Viral sequences were detected at low frequencies (about 5%) in 235 epithelial tumours of adult and paediatric origin, and were absent in 40 control tissues. Our data suggest that SV40 might be a cofactor in the pathogenesis of non-Hodgkin lymphomas.
Author List
Shivapurkar N, Harada K, Reddy J, Scheuermann RH, Xu Y, McKenna RW, Milchgrub S, Kroft SH, Feng Z, Gazdar AFAuthor
Steven Howard Kroft MD Chair, Professor in the Pathology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAged
Aged, 80 and over
Antigens, Viral
Blotting, Southern
Carcinoma
Female
Humans
Lymphoma
Lymphoma, Non-Hodgkin
Male
Middle Aged
Polymerase Chain Reaction
Simian virus 40
