Eicosapentaenoic acid alters vascular reactivity and platelet adhesion in Watanabe heritable hyperlipidemic rabbits. Eur J Pharmacol 1989 Feb 14;161(1):85-9
Date
02/14/1989Pubmed ID
2542038DOI
10.1016/0014-2999(89)90183-0Scopus ID
2-s2.0-0024508487 (requires institutional sign-in at Scopus site) 7 CitationsAbstract
Feeding a diet rich in eicosapentaenoic acid (EPA) to Watanabe heritable hyperlipidemic (WHHL) rabbits resulted in an attenuated aortic contractile response to the vasoconstrictor agent serotonin when compared to responses from WHHL rabbits fed normal rabbit chow. In contrast, only the maximal contractile response to norepinephrine was reduced in EPA-fed rabbit aortas. Additionally, methacholine-induced relaxations were potentiated in aortas obtained from the EPA-fed rabbits. When platelets obtained from EPA-fed rabbits were incubated with arachidonic acid, there was a reduced ability of the platelets to adhere to albumin-coated discs in comparison to control rabbit platelets. These data indicate a potentially beneficial effect of EPA in atherosclerotic WHHL rabbits.
Author List
Pfister SL, Rosolowsky M, Schmitz JM, Clubb FJ Jr, Campbell WBAuthors
William B. Campbell PhD Professor in the Pharmacology and Toxicology department at Medical College of WisconsinSandra L. Pfister PhD Professor in the Pharmacology and Toxicology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AnimalsAorta, Thoracic
Arachidonic Acid
Arachidonic Acids
Diet
Eicosapentaenoic Acid
Fatty Acids
Female
Hemodynamics
Hyperlipidemias
In Vitro Techniques
Male
Platelet Adhesiveness
Potassium Chloride
Rabbits
