Faculty Collaboration Database

Office-based treatment of laryngeal papillomatosis with percutaneous injection of cidofovir. Otolaryngol Head Neck Surg 2002 Jun;126(6):642-8

Date

06/28/2002

Pubmed ID

12087331

DOI

10.1067/mhn.2002.125604

Scopus ID

2-s2.0-0036598224 (requires institutional sign-in at Scopus site)   38 Citations

Abstract

OBJECTIVE: Our aim was to report our experience with office-based treatment of severe laryngeal papillomatosis with percutaneous injection of cidofovir in a case series of 5 patients.

STUDY DESIGN AND SETTING: We conducted a retrospective review of a case series in a tertiary academic care voice disorders clinic. Adult patients with papillomas of the vocal cords and anterior commissure received percutaneous injection using a point-touch technique. Clinical improvement or remission of the papillomatosis was noted.

RESULTS: Before initiation of office treatments, patients required direct laryngoscopy and CO(2) laser ablation of papillomas on average every 2.8 months. There were no complications related to the injection technique. During a treatment period of 7 to 16 months (mean 12 months), a significant reduction in the volume of papillomatosis was achieved in all patients. One patient received 2 treatments and another received 1 treatment in the operating room for final clearance of papillomas.

CONCLUSION: Office-based treatment of adult patients with anterior laryngeal papillomatosis using percutaneous injection of cidofovir reduces the need for repeated direct laryngoscopy and laser ablation under general anesthesia.

SIGNIFICANCE: Percutaneous injection treatment with cidofovir is a useful adjunct to direct laryngoscopy and laser ablation in the treatment of laryngeal papillomatosis.

Author List

Chhetri DK, Blumin JH, Shapiro NL, Berke GS

Author

Joel H. Blumin MD Chief, Professor in the Otolaryngology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Ambulatory Care
Antineoplastic Agents
Cytosine
Female
Follow-Up Studies
Humans
Injections, Intralesional
Laryngeal Neoplasms
Laryngoscopy
Male
Middle Aged
Neoplasm Recurrence, Local
Organophosphonates
Organophosphorus Compounds
Papilloma
Retrospective Studies
Sampling Studies
Severity of Illness Index
Treatment Outcome