Faculty Collaboration Database

Within-subject joint independent component analysis of simultaneous fMRI/ERP in an auditory oddball paradigm. Neuroimage 2012 May 01;60(4):2247-57

Date

03/02/2012

Pubmed ID

22377443

Pubmed Central ID

PMC3321114

DOI

10.1016/j.neuroimage.2012.02.030

Scopus ID

2-s2.0-84858741593 (requires institutional sign-in at Scopus site)   31 Citations

Abstract

The integration of event-related potential (ERP) and functional magnetic resonance imaging (fMRI) can contribute to characterizing neural networks with high temporal and spatial resolution. This research aimed to determine the sensitivity and limitations of applying joint independent component analysis (jICA) within-subjects, for ERP and fMRI data collected simultaneously in a parametric auditory frequency oddball paradigm. In a group of 20 subjects, an increase in ERP peak amplitude ranging 1-8 μV in the time window of the P300 (350-700 ms), and a correlated increase in fMRI signal in a network of regions including the right superior temporal and supramarginal gyri, was observed with the increase in deviant frequency difference. JICA of the same ERP and fMRI group data revealed activity in a similar network, albeit with stronger amplitude and larger extent. In addition, activity in the left pre- and post-central gyri, likely associated with right hand somato-motor response, was observed only with the jICA approach. Within-subject, the jICA approach revealed significantly stronger and more extensive activity in the brain regions associated with the auditory P300 than the P300 linear regression analysis. The results suggest that with the incorporation of spatial and temporal information from both imaging modalities, jICA may be a more sensitive method for extracting common sources of activity between ERP and fMRI.

Author List

Mangalathu-Arumana J, Beardsley SA, Liebenthal E

Author

Scott Beardsley PhD Associate Professor in the Biomedical Engineering department at Marquette University

MESH terms used to index this publication - Major topics in bold

Acoustic Stimulation
Adolescent
Adult
Brain
Brain Mapping
Electroencephalography
Event-Related Potentials, P300
Female
Humans
Image Interpretation, Computer-Assisted
Magnetic Resonance Imaging
Male
Principal Component Analysis
Young Adult