Effects of prednisone and ibuprofen on radio frequency volume tissue reduction in a rabbit model. Ann Otol Rhinol Laryngol 2002 Nov;111(11):968-71
Date
11/27/2002Pubmed ID
12450168DOI
10.1177/000348940211101103Scopus ID
2-s2.0-0036847098 (requires institutional sign-in at Scopus site) 4 CitationsAbstract
This study investigates whether acute anti-inflammatory medications (prednisone and ibuprofen) alter muscle volumetric reduction following radio frequency tissue ablation (RFTA). We used a rabbit model to measure changes in leg muscle volume using serial magnetic resonance imaging in 3 groups: RFTA without medication (group 1), RFTA with prednisone and ibuprofen (group 2), and no RFTA or medication (group 3). The mean volumetric changes for groups I and 2 differed on days 1 and 7 (+0.5 cm3 versus -0.4 cm3, p < .0001; and -0.03 cm3 versus -0.7 cm3, p < .05), but not on day 28 (-0.8 cm3 versus -1.0 cm3, not significant). Group 3 had no change in volume. The volumetric reduction varied. Impaired volumetric reduction (<50% mean change) occurred in 30% of extremities and correlated to lower tissue impedance (p < .04). Combined steroidal and nonsteroidal anti-inflammatory medications did decrease acute edema, but not the final volumetric reduction, following RFTA. Volumetric changes are variable and may be altered by tissue impedance.
Author List
Han JK, Woodson BTAuthor
B Tucker Woodson MD Chief, Professor in the Otolaryngology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsAnti-Inflammatory Agents
Anti-Inflammatory Agents, Non-Steroidal
Data Interpretation, Statistical
Disease Models, Animal
Electrosurgery
Female
Ibuprofen
Magnetic Resonance Imaging
Male
Muscle, Skeletal
Prednisone
Rabbits
Sleep Apnea Syndromes
Wound Healing
