Effect of chronic and acute cigarette smoking on the pharyngoglottal closure reflex. Gut 2002 Dec;51(6):771-5
Date
11/13/2002Pubmed ID
12427774Pubmed Central ID
PMC1773456DOI
10.1136/gut.51.6.771Scopus ID
2-s2.0-0036895020 (requires institutional sign-in at Scopus site) 33 CitationsAbstract
BACKGROUND: Injection of water into the pharynx at a threshold volume induces vocal cord adduction--the pharyngoglottal closure reflex (PGCR). This reflex together with other supraoesophageal reflexes may be helpful in preventing aspiration. Cigarette smoking has an adverse affect on the pharyngo-upper oesophageal sphincter contractile reflex and reflexive pharyngeal swallow. The effect of smoking on PGCR has not been studied previously.
AIMS: To elucidate the effect of chronic and acute cigarette smoking on PGCR.
SUBJECTS: We studied 10 chronic smokers and 10 non-smokers before and after real/simulated smoking, respectively.
METHODS: Using concurrent recordings, glottal function was monitored by video endoscopy, swallowing by electromyography, and PGCR was triggered by rapid and slow pharyngeal water injections.
RESULTS: The threshold volume to trigger PGCR during rapid injection was significantly higher in chronic smokers (non-smoker 0.20 (SEM 0.02) ml, smoker 0.36 (0.02) ml; p<0.001). In six of 10 smokers, acute smoking abolished this reflex during slow water injection.
CONCLUSIONS: Smoking adversely affects stimulation of PGCR. This finding may have implications in the development of reflux related respiratory complications in smokers.
Author List
Dua K, Bardan E, Ren J, Sui Z, Shaker RAuthors
Kulwinder S. Dua MD Professor in the Medicine department at Medical College of WisconsinReza Shaker MD Assoc Provost, Sr Assoc Dean, Ctr Dir, Chief, Prof in the Medicine department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AdultCase-Control Studies
Female
Glottis
Humans
Laryngoscopy
Male
Pharynx
Pneumonia, Aspiration
Reflex
Smoking
Video Recording
