Severe central sleep apnea in a child with leukemia on chronic methadone therapy. Pediatr Pulmonol 2013 Jan;48(1):85-7
Date
03/21/2012Pubmed ID
22431505DOI
10.1002/ppul.22539Scopus ID
2-s2.0-84872860894 (requires institutional sign-in at Scopus site) 8 CitationsAbstract
We describe a child with acute myeloid leukemia (AML) who developed severe central sleep apnea (CSA) on methadone therapy for chronic pain management. His chemotherapy-related cerebral atrophy and renal insufficiency with impaired methadone clearance may have also contributed to the severity of his sleep-disordered breathing. Maintenance methadone treatment is not a common pediatric practice; therefore, the adverse effects of methadone therapy, including CSA, are rarely reported in children.
Author List
Amos LB, D'Andrea LAAuthors
Louella B. Amos MD Associate Professor in the Pediatrics department at Medical College of WisconsinLynn A. D Andrea MD Chief, Professor in the Pediatrics department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
Analgesics, OpioidChild
Humans
Leukemia, Myeloid, Acute
Male
Methadone
Pain
Severity of Illness Index
Sleep Apnea, Central