Identification of hypertension-related QTLs in African American sib pairs. Hypertension 2002 Nov;40(5):634-9
Date
11/02/2002Pubmed ID
12411455DOI
10.1161/01.hyp.0000036400.79248.22Scopus ID
2-s2.0-0036840308 (requires institutional sign-in at Scopus site) 22 CitationsAbstract
To link hypertension-related phenotypes with chromosomal loci, genome scans were performed in 150 African American sib pairs concordant for essential hypertension. Phenotypes included blood pressure, anthropomorphic measurements, and estimates of body fluid compartments as determined by impedance plethysmography. These phenotypes were also measured in 335 normotensive African Americans. Phenotypes with LOD scores >3.3 were further evaluated for significance by use of permutation procedures. Significant linkage was detected for body mass index (BMI) on chromosomes 1 and 8 and for the ratio of extracellular water to total body water (ECF/TBW) on chromosomes 3, 5, 6, and 7. Both BMI and ECF/TBW were greater in hypertensive sibs than in normotensive subjects (P<0.001). In a subset of hypertensive sibs and normotensive subjects, average 24-hour blood pressures were correlated with ECF/TBW (P<0.01). A region linked to BMI in the hypertensive sibs corresponds to a region of conserved synteny containing blood pressure-related QTLs in an F2 cross of Brown NorwayxDahl salt-sensitive rats. Focusing on hypertension-related phenotypes is a promising approach for identifying the genetic determinants of hypertension.
Author List
Kotchen TA, Broeckel U, Grim CE, Hamet P, Jacob H, Kaldunski ML, Kotchen JM, Schork NJ, Tonellato PJ, Cowley AW JrAuthors
Ulrich Broeckel MD Chief, Center Associate Director, Professor in the Pediatrics department at Medical College of WisconsinAllen W. Cowley Jr PhD Professor in the Physiology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AdolescentAdult
Blood Pressure
Body Fluid Compartments
Body Mass Index
Body Water
Chromosome Mapping
Chromosomes, Human
Electric Impedance
Female
Genetic Linkage
Humans
Hypertension
Lod Score
Male
Middle Aged
Phenotype
Plethysmography, Whole Body
Quantitative Trait Loci
Siblings
Synteny
Wisconsin
