Faculty Collaboration Database

Visual object agnosia and pure word alexia: correlation of functional magnetic resonance imaging and lesion localization. J Comput Assist Tomogr 2004;28(1):63-7

Date

01/13/2004

Pubmed ID

14716234

DOI

10.1097/00004728-200401000-00010

Scopus ID

2-s2.0-0347355232 (requires institutional sign-in at Scopus site)   22 Citations

Abstract

We present a case of a 64-year-old, right-handed female with a metastatic breast cancer lesion involving the left posterior inferior temporal lobe causing complete loss of the ability to recognize visually common objects and words. After her symptoms resolved on corticosteroid therapy, functional magnetic resonance imaging (fMRI) mapping demonstrated strong left-hemispheric dominance for word recognition and right-hemispheric dominance for object recognition. The case illustrates the relationships among ventral occipito-temporal cortical activation, lesion localization, and lesion-induced deficits of higher visual function. The relationship between hemispheric dominance determined by fMRI and risk of postoperative deficit depends on the specific visual function of interest.

Author List

Salvan CV, Ulmer JL, DeYoe EA, Wascher T, Mathews VP, Lewis JW, Prost RW

Authors

Edgar A. DeYoe PhD Adjunct Professor in the Radiology department at Medical College of Wisconsin
Vincent Mathews MD Chair, Professor in the Radiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Agnosia
Brain Mapping
Brain Neoplasms
Breast Neoplasms
Cerebral Cortex
Dominance, Cerebral
Dyslexia, Acquired
Female
Humans
Magnetic Resonance Imaging
Middle Aged
Temporal Lobe
Visual Perception