Granulocyte transfusions in fulminant invasive fungal sinusitis. Am J Otolaryngol 2012;33(6):663-6
Date
06/12/2012Pubmed ID
22682953DOI
10.1016/j.amjoto.2012.04.001Scopus ID
2-s2.0-84868338885 (requires institutional sign-in at Scopus site) 2 CitationsAbstract
PURPOSE: Fulminant invasive fungal sinusitis (IFS) is an aggressive disease seen in patients who are severely neutropenic. The use of granulocyte transfusions to address neutropenia-associated IFS has been described for almost 2 decades. The objectives are to provide our experience using granulocyte transfusions in patients with IFS and to provide a current review of the literature.
MATERIALS AND METHODS: A retrospective chart review was performed at the Medical College of Wisconsin to identify patients who received granulocyte transfusions for IFS. Data collected included age, original diagnosis, IFS pathogen, dates, transfusion number, reason for discontinuation, additional therapies, last known follow-up, and status at last known follow-up. A Medline search and manual review of citations within bibliographies was also performed.
RESULTS: A total of 20 patients received granulocyte transfusions at the Medical College of Wisconsin between October 2003 and June 2009; 3 of these patients received granulocyte transfusions for fulminant IFS. A total of 22 reported cases of IFS treated with granulocyte transfusions exist in the current literature.
CONCLUSIONS: Although limitations to the use of granulocyte transfusions exist, they still represent a viable treatment option in individuals who fail to respond to more conventional therapies.
Author List
Carter KB Jr, Loehrl TA, Poetker DMAuthor
David M. Poetker MD Chief, Professor in the Otolaryngology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Acute DiseaseAdolescent
Adult
Female
Follow-Up Studies
Granulocytes
Humans
Leukocyte Transfusion
Male
Middle Aged
Mycoses
Retrospective Studies
Sinusitis
Treatment Outcome
Young Adult
