Faculty Collaboration Database

Optimistic expectations and survival after hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2003 Jun;9(6):389-96

Date

06/19/2003

Pubmed ID

12813447

DOI

10.1016/s1083-8791(03)00103-4

Scopus ID

2-s2.0-1542787244 (requires institutional sign-in at Scopus site)   49 Citations

Abstract

An optimistic attitude is hypothesized to be beneficial when facing a life-threatening medical condition. However, the actual relationship of high expectations for treatment success and medical outcome is controversial. Using a prospective cohort of 313 autologous and allogeneic hematopoietic stem cell transplant patients enrolled July 1996 through November 1999, we tested whether patient-reported expectations before transplantation were associated with survival and quality of life following the procedure. Before transplantation, patients with higher expectations that the transplant procedure would go well had better mental and emotional functioning, but similar physical status and medical condition to patients with less optimistic expectations. In the first 2 months after transplantation, optimistic expectations were associated with better survival (92% v 84%; relative risk for mortality 0.45, 95% confidence interval 0.22-0.92; P=.03) controlling for other physical and mental characteristics. However, by 6 months posttransplantation, survival and quality of life were indistinguishable between patients with initially higher and lower expectations. Our data suggest an association between more optimistic expectations and early survival following hematopoietic stem cell transplantation, but this association is not present by 6 months posttransplantation.

Author List

Lee SJ, Loberiza FR, Rizzo JD, Soiffer RJ, Antin JH, Weeks JC

Author

J. Douglas Rizzo MD, MS Director, Center Associate Director, Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Aged
Attitude to Health
Female
Follow-Up Studies
Hematologic Neoplasms
Humans
Longitudinal Studies
Male
Marriage
Middle Aged
Peripheral Blood Stem Cell Transplantation
Prospective Studies
Quality of Life
Risk
Socioeconomic Factors
Survival Analysis
Time Factors
Transplantation, Autologous
Transplantation, Homologous
Treatment Outcome