Faculty Collaboration Database

The co-existence of geriatric depression and amnestic mild cognitive impairment detrimentally affect gray matter volumes: voxel-based morphometry study. Behav Brain Res 2012 Dec 01;235(2):244-50

Date

08/23/2012

Pubmed ID

22909988

Pubmed Central ID

PMC3561929

DOI

10.1016/j.bbr.2012.08.007

Scopus ID

2-s2.0-84865572922 (requires institutional sign-in at Scopus site)   49 Citations

Abstract

While late-life depression (LLD) and amnestic mild cognitive impairment (aMCI), alone and in combination, is associated with an increased risk of incident Alzheimer's disease (AD), the neurobiological mechanisms of this link are unclear. We examined the main and interactive effects of LLD and aMCI on the gray matter (GM) volumes in 72 physically healthy participants aged 60 and older. Participants were separated into normal controls, cognitively normal depressed, non-depressed aMCI, and depressed aMCI groups. Optimized voxel-based morphometry estimated GM volumes. The main and interactive effects of LLD and aMCI, and of depressive symptoms and episodic memory deficits on the GM volumes were analyzed. While decreased GM volumes in the mood regulating circuitry structures were associated with depression, GM atrophy in regions essential for various cognitive performance were related to aMCI. LLD-aMCI interactions were associated with widespread subcortical and cortical GM volume loss of brain structures implicated in AD. The interactions between episodic memory deficits and depressive symptom severity are associated with volume loss in right inferior frontal gyrus/anterior insula and left medial frontal gyrus clusters. Our findings suggest that the co-existence of these clinical phenotypes is a potential marker for higher risk of AD.

Author List

Xie C, Li W, Chen G, Douglas Ward B, Franczak MB, Jones JL, Antuono PG, Li SJ, Goveas JS

Authors

Piero G. Antuono MD Professor in the Neurology department at Medical College of Wisconsin
Malgorzata Franczak MD Professor in the Neurology department at Medical College of Wisconsin
Joseph S. Goveas MD Professor in the Psychiatry and Behavioral Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Activities of Daily Living
Aged
Aged, 80 and over
Analysis of Variance
Brain
Brain Mapping
Cognitive Dysfunction
Depression
Female
Geriatric Assessment
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Middle Aged
Neuropsychological Tests
Psychiatric Status Rating Scales