Including aortic valve morphology in computational fluid dynamics simulations: initial findings and application to aortic coarctation. Med Eng Phys 2013 Jun;35(6):723-35
Date
08/25/2012Pubmed ID
22917990Pubmed Central ID
PMC3577975DOI
10.1016/j.medengphy.2012.07.015Scopus ID
2-s2.0-84888286278 (requires institutional sign-in at Scopus site) 36 CitationsAbstract
Computational fluid dynamics (CFD) simulations quantifying thoracic aortic flow patterns have not included disturbances from the aortic valve (AoV). 80% of patients with aortic coarctation (CoA) have a bicuspid aortic valve (BAV) which may cause adverse flow patterns contributing to morbidity. Our objectives were to develop a method to account for the AoV in CFD simulations, and quantify its impact on local hemodynamics. The method developed facilitates segmentation of the AoV, spatiotemporal interpolation of segments, and anatomic positioning of segments at the CFD model inlet. The AoV was included in CFD model examples of a normal (tricuspid AoV) and a post-surgical CoA patient (BAV). Velocity, turbulent kinetic energy (TKE), time-averaged wall shear stress (TAWSS), and oscillatory shear index (OSI) results were compared to equivalent simulations using a plug inlet profile. The plug inlet greatly underestimated TKE for both examples. TAWSS differences extended throughout the thoracic aorta for the CoA BAV, but were limited to the arch for the normal example. OSI differences existed mainly in the ascending aorta for both cases. The impact of AoV can now be included with CFD simulations to identify regions of deleterious hemodynamics thereby advancing simulations of the thoracic aorta one step closer to reality.
Author List
Wendell DC, Samyn MM, Cava JR, Ellwein LM, Krolikowski MM, Gandy KL, Pelech AN, Shadden SC, LaDisa JF JrAuthors
Joseph R. Cava MD, PhD Associate Professor in the Pediatrics department at Medical College of WisconsinJohn F. LaDisa PhD Professor in the Pediatrics department at Medical College of Wisconsin
Margaret Mary Samyn MD Professor in the Pediatrics department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AdolescentAdult
Aortic Coarctation
Aortic Valve
Computer Simulation
Female
Hemodynamics
Humans
Hydrodynamics
Kinetics
Male
Stress, Mechanical
