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Gastroesophageal reflux disease in lung transplant patients with cystic fibrosis. Am J Surg 2012 Nov;204(5):e21-6

Date

08/28/2012

Pubmed ID

22921151

DOI

10.1016/j.amjsurg.2012.07.019

Scopus ID

2-s2.0-84868600857   25 Citations

Abstract

BACKGROUND: Gastroesophageal reflux disease (GERD) in lung transplant patients is being increasingly investigated because of its reported association with chronic rejection. However, information concerning the characteristics of GERD in cystic fibrosis (CF) patients is scarce.

METHODS: We compared esophageal pH monitoring, manometry, gastric emptying studies, and barium swallow of 10 lung transplant patients with CF with those of 78 lung transplant patients with other end-stage pulmonary diseases.

RESULTS: In lung transplant patients with CF, the prevalence of GERD was 90% (vs 54% controls, P = .04), of whom 70% had proximal reflux (vs 29% controls, P = .02).

CONCLUSIONS: Lung transplant patients with CF have a significantly higher prevalence and proximal extent of GERD than do other lung transplant recipients. These data suggest that CF patients in particular should be routinely screened for GERD after transplantation to identify those who may benefit from antireflux surgery, especially given the risks of GERD-related aspiration and chronic allograft injury.

Author List

Mendez BM, Davis CS, Weber C, Joehl RJ, Fisichella PM

Author

Christopher Stephen Davis MD, MPH Assistant Professor in the Surgery department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adolescent
Adult
Aged
Barium Sulfate
Case-Control Studies
Contrast Media
Cystic Fibrosis
Esophageal pH Monitoring
Female
Gastric Emptying
Gastroesophageal Reflux
Humans
Lung Transplantation
Male
Manometry
Middle Aged
Postoperative Complications
Prevalence
Retrospective Studies
Young Adult
jenkins-FCD Prod-482 91ad8a360b6da540234915ea01ff80e38bfdb40a