Glucose administration augments in vivo uptake and phototoxicity of the tumor-localizing fraction of hematoporphyrin derivative. Photochem Photobiol 1989 Mar;49(3):241-7
Date
03/01/1989Pubmed ID
2525259DOI
10.1111/j.1751-1097.1989.tb04102.xScopus ID
2-s2.0-0024639109 (requires institutional sign-in at Scopus site) 70 CitationsAbstract
Rhabdomyosarcoma tumors in rats made hyperglycemic by multiple injections of glucose exhibited a transient decrease in pH and an increased ability to accumulate derivatives of hematoporphyrin (HPD). Photoradiation of tumors in glucose/HPD-treated animals produced a greater cell kill than in galactose/HPD-treated controls. A therapeutic benefit of glucose administration in conjunction with HPD-phototherapy is suggested.
Author List
Thomas JP, Girotti AWAuthor
James P. Thomas MD, PhD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsAntineoplastic Agents
Biological Transport
Cell Line
Cell Survival
Galactose
Glucose
Hematoporphyrin Derivative
Hematoporphyrins
Humans
Hydrogen-Ion Concentration
Kinetics
Male
Photolysis
Rats
Rats, Inbred Strains
Rhabdomyosarcoma
Tumor Cells, Cultured
