Faculty Collaboration Database

Prophylactic cranial irradiation for patients with locally advanced non-small-cell lung cancer. Oncology (Williston Park) 2003 Jun;17(6):775-9; discussion 779-80, 784, 787 passim

Date

07/09/2003

Pubmed ID

12846122

Scopus ID

2-s2.0-0042853137 (requires institutional sign-in at Scopus site)   9 Citations

Abstract

Over the past decade, studies have shown improved survival in patients with locally advanced non-small-cell lung cancer. This can be attributed to better systemic therapy, growing experience with combined-modality therapy, technologic advances allowing for increased radiation doses, better supportive care, and better patient selection. With longer survival, we are seeing an increase in the incidence of central nervous system (CNS) metastases. Prophylactic cranial irradiation (PCI) decreases the incidence of CNS metastases in these patients and may have a favorable impact on quality of life and overall survival. This paper reviews the incidence of CNS metastases in non-small-cell lung cancer patients, past experience with PCI, and a current study evaluating the impact of PCI on survival, neuropsychological function, and quality of life.

Author List

Gore EM

Author

Elizabeth M. Gore MD Professor in the Radiation Oncology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Brain Neoplasms
Carcinoma, Non-Small-Cell Lung
Cognition Disorders
Cranial Irradiation
Humans
Lung Neoplasms
Prognosis
Quality of Life
Survival Analysis