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Successful treatment of tumor-induced osteomalacia with CT-guided percutaneous ethanol and cryoablation. J Clin Endocrinol Metab 2012 Oct;97(10):3421-5

Date

07/28/2012

Pubmed ID

22837186

DOI

10.1210/jc.2012-1719

Scopus ID

2-s2.0-84867244983   19 Citations

Abstract

CONTEXT: Tumor-induced osteomalacia is a rare condition usually caused by benign mesenchymal tumors. When the tumor can be found, patients are usually managed by wide excision of the tumor.

OBJECTIVE: We report a 51-yr-old male with clinical and biochemical evidence of tumor-induced osteomalacia caused by a mesenchymal tumor in the right iliac bone. He declined surgery and appears to have been successfully managed by computed tomography-guided percutaneous ethanol ablation and percutaneous cryoablation.

RESULTS: Our patient appears to have had an excellent clinical and biochemical response to computed tomography-guided percutaneous ethanol ablation and percutaneous cryoablation. We found one prior case of image-guided ablation using radiofrequency ablation for tumor-induced osteomalacia.

CONCLUSIONS: Although the standard treatment for tumor-induced osteomalacia is wide excision of the tumor, image-guided ablation may be an option in patients who cannot have appropriate surgery or who decline surgery.

Author List

Tutton S, Olson E, King D, Shaker JL

Authors

David M. King MD Chair, Professor in the Orthopaedic Surgery department at Medical College of Wisconsin
Joseph L. Shaker MD Staff Physician in the Multi-Specialty department at Medical College of Wisconsin
Sean Tutton MD Vice Chair, Professor in the Radiology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Cryosurgery
Ethanol
Humans
Male
Mesenchymoma
Middle Aged
Neoplasms, Connective Tissue
Osteomalacia
Solvents
Tomography, X-Ray Computed
jenkins-FCD Prod-480 9a4deaf152b0b06dd18151814fff2e18f6c05280