Stem cell donation--what advice can be given to the donor? Br J Haematol 2009 Oct;147(1):71-6
Date
08/18/2009Pubmed ID
19681886Pubmed Central ID
PMC3409390DOI
10.1111/j.1365-2141.2009.07832.xScopus ID
2-s2.0-70349203764 (requires institutional sign-in at Scopus site) 10 CitationsAbstract
Haematopoietic stem cell transplantation (HSCT) is widely used to treat patients with a range of haematological and non-haematological disorders. Both bone marrow and peripheral blood stem cell collection are associated with morbidity and, very rarely, mortality. We investigated the information that exists to adequately inform donors about the relative merits of each procedure. We carried out a systematic review analysing data from six prospective randomised controlled trials of related donors and discuss here the merits and drawbacks of this approach. Registry data mostly describes patient outcome but stem cell donor registries collect and report information on unrelated donors which could easily be extended to related donors. Further well-designed, randomised studies are required.
Author List
Pamphilon D, Siddiq S, Brunskill S, Dorée C, Hyde C, Horowitz M, Stanworth SAuthor
Mary M. Horowitz MD, MS Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Donor SelectionEvidence-Based Medicine
Health Education
Hematopoietic Stem Cell Transplantation
Humans
Randomized Controlled Trials as Topic
Registries
Tissue Donors
Tissue and Organ Harvesting
