Faculty Collaboration Database

Pulmonary embolism in patients with CKD and ESRD. Clin J Am Soc Nephrol 2012 Oct;7(10):1584-90

Date

07/28/2012

Pubmed ID

22837271

Pubmed Central ID

PMC3463201

DOI

10.2215/CJN.00250112

Scopus ID

2-s2.0-84867255666 (requires institutional sign-in at Scopus site)   69 Citations

Abstract

BACKGROUND AND OBJECTIVES: CKD and ESRD are growing burdens. It is unclear whether these conditions affect pulmonary embolism (PE) risk, given that they affect both procoagulant and anticoagulant factors. This study examined the frequency and associated outcomes of PE in CKD and ESRD.

DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: The Healthcare Cost and Utilization Project's Nationwide Inpatient Sample was used to estimate the frequency and outcomes of PE in adults with CKD and ESRD. Hospitalizations for the principal diagnosis of PE and presence of CKD or ESRD were identified using International Classification of Diseases, Ninth Revision codes. Data from the annual US Census and US Renal Data System reports were used to calculate the number of adults with CKD, ESRD, and normal kidney function (NKF) as well as the annual incidence of PE in each group. Logistic regression modeling was used to compare in-hospital mortality among persons admitted for PE who had ESRD or CKD to those without these conditions.

RESULTS: The annual frequency of PE was 527 per 100,000, 204 per 100,000, and 66 per 100,000 persons with ESRD, CKD, and NKF, respectively. In-hospital mortality was higher for persons with ESRD and CKD (P<0.001) compared with persons with NKF. Median length of stay was longer by 1 day in CKD and 2 days in ESRD than among those with NKF.

CONCLUSIONS: Persons with CKD and ESRD are more likely to have PE than persons with NKF. Once they have PE, they are more likely to die in the hospital.

Author List

Kumar G, Sakhuja A, Taneja A, Majumdar T, Patel J, Whittle J, Nanchal R, Milwaukee Initiative in Critical Care Outcomes Research (MICCOR) Group of Investigators

Authors

Rahul Sudhir Nanchal MD Professor in the Medicine department at Medical College of Wisconsin
Jayshil Patel MD Associate Professor in the Medicine department at Medical College of Wisconsin
Amit Taneja MD Assistant Professor in the Medicine department at Medical College of Wisconsin
Jeffrey Whittle MD Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Aged
Case-Control Studies
Female
Hospital Mortality
Hospitalization
Humans
Incidence
Kidney Failure, Chronic
Length of Stay
Logistic Models
Male
Middle Aged
Multivariate Analysis
Odds Ratio
Pulmonary Embolism
Renal Insufficiency, Chronic
Risk Factors
Thrombolytic Therapy
Time Factors
United States
Vena Cava Filters
Young Adult