Medical College of Wisconsin
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External auditory canal eccrine spiradenocarcinoma: a case report and review of literature. Head Neck 2003 Jun;25(6):505-10



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BACKGROUND: Eccrine spiradenocarcinoma is a rare dermal appendage carcinoma believed to arise from transformation of a long-standing benign spiradenoma. This tumor demonstrates highly malignant biologic behavior with a high recurrence rate, frequent lymph node metastases, and overall poor survival.

METHODS: We report the first case of eccrine spiradenocarcinoma arising in the external auditory canal. The management of this tumor, its histopathologic characteristics, and a review of literature are presented.

RESULTS: A literature review identified 17 cases of eccrine spiradenocarcinoma in the head and neck region. Local recurrence occurred in 58.8% of patients, with an average of 23 months from diagnosis. Lymph node metastasis occurred in 35.3%, with an average of 31 months from diagnosis. Other metastatic sites included skin, bone, and lung. Disease-specific mortality was 22.2%.

CONCLUSIONS: Eccrine spiradenocarcinoma is an aggressive tumor with a poor prognosis. Primary treatment should include wide local excision with or without regional lymphadenectomy. Isolated successful treatments have been documented with adjuvant hormonal manipulation, chemotherapy, and radiation therapy.

Author List

Meyer TK, Rhee JS, Smith MM, Cruz MJ, Osipov VO, Wackym PA


Michelle A. Michel MD Clinical Professor in the Radiology department at Medical College of Wisconsin
John S. Rhee MD Chair, Professor in the Otolaryngology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Ear Canal
Ear Neoplasms
Middle Aged
Neoplasms, Adnexal and Skin Appendage
jenkins-FCD Prod-478 d1509cf07a111124a2d122fd3df854cc0b993c00