Does matched unrelated donor transplantation have the same outcome as matched sibling transplantation in unselected patients? Best Pract Res Clin Haematol 2012 Dec;25(4):483-6
Date
12/04/2012Pubmed ID
23200546Pubmed Central ID
PMC6432637DOI
10.1016/j.beha.2012.10.012Scopus ID
2-s2.0-84870694832 (requires institutional sign-in at Scopus site) 24 CitationsAbstract
Outcome differences by donor type for allogeneic hematopoietic stem cell transplantation vary based on disease and recipient age. The following paper summarizes analyses of transplant outcome among adults with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) who received transplants from HLA-identical siblings, fully (8/8) matched unrelated donors (MUD), or mismatched (7/8) unrelated donors. The paper also reviews transplantation outcomes for children with leukemia who had genotypically matched sibling donors, mismatched (7/8) or phenotypically matched related donors or matched (8/8) unrelated donors. Morbidity is higher after unrelated donor vs HLA-matched sibling transplants due to higher rates of acute graft-vs-host disease (GVHD). However, survival is similar or within 10%-15% with all studies donor type, with disease-specific differences probably reflecting differences in underlying population risk for treatment-related mortality.
Author List
Horowitz MMAuthor
Mary M. Horowitz MD, MS Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Acute DiseaseAdult
Child
Child, Preschool
Disease-Free Survival
Donor Selection
Female
Graft vs Host Disease
Hematopoietic Stem Cell Transplantation
Histocompatibility Testing
Humans
Infant
Leukemia, Myeloid, Acute
Male
Myelodysplastic Syndromes
Risk Factors
Siblings
Survival Rate
Transplantation, Homologous
