Differential effects of deep sedation with propofol on the specific and nonspecific thalamocortical systems: a functional magnetic resonance imaging study. Anesthesiology 2013 Jan;118(1):59-69
Date
12/12/2012Pubmed ID
23221862Pubmed Central ID
PMC4080838DOI
10.1097/ALN.0b013e318277a801Scopus ID
2-s2.0-84871617057 (requires institutional sign-in at Scopus site) 122 CitationsAbstract
BACKGROUND: The current state of knowledge suggests that disruption of neuronal information integration may be a common mechanism of anesthetic-induced unconsciousness. A neural system critical for information integration is the thalamocortical system whose specific and nonspecific divisions may play the roles for representing and integrating information, respectively. How anesthetics affect the function of these systems individually is not completely understood. The authors studied the effect of propofol on thalamocortical functional connectivity in the specific and nonspecific systems, using functional magnetic resonance imaging.
METHODS: Eight healthy volunteers were instructed to listen to and encode 40 English words during wakeful baseline, light sedation, deep sedation, and recovery in the scanner. Functional connectivity was determined as the temporal correlation of blood oxygen level-dependent signals with seed regions defined within the specific and nonspecific thalamic nuclei.
RESULTS: Thalamocortical connectivity at baseline was dominantly medial and bilateral frontal and temporal for the specific system, and medial frontal and medial parietal for the nonspecific system. During deep sedation, propofol reduced functional connectivity by 43% (specific) and 79% (nonspecific), a significantly greater reduction in the nonspecific than in the specific system and in the left hemisphere than in the right. Upon regaining consciousness, functional connectivity increased by 58% (specific) and 123% (nonspecific) during recovery, exceeding their values at baseline.
CONCLUSIONS: Propofol conferred differential changes in functional connectivity of the specific and nonspecific thalamocortical systems, particularly in left hemisphere, consistent with the verbal nature of stimuli and task. The changes in nonspecific thalamocortical connectivity may correlate with the loss and return of consciousness.
Author List
Liu X, Lauer KK, Ward BD, Li SJ, Hudetz AGAuthor
Kathryn K. Lauer MD Vice Chair, Professor in the Anesthesiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAnesthetics, Intravenous
Brain
Deep Sedation
Echo-Planar Imaging
Female
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Nerve Net
Neural Pathways
Propofol
Reference Values
Thalamic Nuclei
Wakefulness
Young Adult
