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Abnormalities of cortical thickness in postictal psychosis. Epilepsy Behav 2011 Jun;21(2):132-6

Date

05/06/2011

Pubmed ID

21543262

DOI

10.1016/j.yebeh.2011.03.024

Scopus ID

2-s2.0-79958723047   12 Citations

Abstract

Postictal psychosis (PIP), the occurrence of psychotic episodes following a seizure, is a common and serious comorbidity in patients with epilepsy. Yet, the anatomical correlates remain poorly defined. Here, we used quantitative MRI morphometry to identify structural abnormalities in the cortex of patients with PIP relative to patients with epilepsy without PIP and age- and gender-matched normal healthy controls. Comparison of patients with epilepsy and PIP with patients with epilepsy without PIP revealed increased cortical thickness in the right lateral prefrontal cortex, right anterior cingulate cortex, and right middle temporal gyrus. The PIP group was distinguished from the EC and NC groups by thicker cortex in the right rostral anterior cingulate cortex and thinner cortex in the right angular gyrus and the left middle temporal region. Findings indicate that PIP is associated with thickening of the right anterior cingulate cortex, which may serve as a marker for patients at risk for developing PIP.

Author List

DuBois JM, Devinsky O, Carlson C, Kuzniecky R, Quinn BT, Alper K, Butler T, Starner K, Halgren E, Thesen T

Author

Chad Carlson MD Professor in the Neurology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adult
Brain Mapping
Cerebral Cortex
Electroencephalography
Epilepsy
Female
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Middle Aged
Psychotic Disorders
Seizures
Videotape Recording