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The effect of pulse sequence parameters and contrast agent dose on percentage signal recovery in DSC-MRI: implications for clinical applications. AJNR Am J Neuroradiol 2013 Jul;34(7):1364-9



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2-s2.0-84880846810   21 Citations


BACKGROUND AND PURPOSE: Both technical and pathophysiologic factors affect PSR in DSC-MR imaging. We aimed to determine how TE, flip angle (I?), and contrast dose impact PSR in high-grade gliomas.

MATERIALS AND METHODS: We retrospectively computed PSR maps for 22 patients with high-grade gliomas, comparing 3 DSC-MR imaging methods by using single-dose gadodiamide without preload administration: A (n = 7), I? = 35A?, TE = 54 ms; B (n = 5), I? = 72A?, TE = 30 ms; C (n = 10), I? = 90A?, TE = 30 ms. Methods A-C served as preload for subsequent dynamic imaging using method D (method C parameters but with double-dose contrast). We compared first- and second-injection tumor PSR for methods C and D (paired t test) and tumor PSR for both injections grouped by the first-injection acquisition method (3-group nonparametric 1-way ANOVA). We compared PSR in tumor and normal brain for each first- and second-injection method group (paired t test).

RESULTS: First-injection PSR in tumor and normal brain differed significantly for methods B (P = .01) and C (P = .05), but not A (P = .71). First-injection tumor PSR increased with T1 weighting with a significant main effect of method groupings (P = .0012), but there was no significant main effect for first-injection normal brain (P = .93), or second-injection tumor (P = .95) or normal brain (P = .13). In patients scanned with methods C and D, first-injection PSR significantly exceeded second-injection PSR for tumor (P = .037) and normal brain (P < .001).

CONCLUSIONS: PSR strongly depends on the T1 weighting of DSC-MR imaging, including pulse sequence (TE, I?) and contrast agent (dose, preload) parameters, with implications for protocol design and the interpretation and comparison of PSR values across tumor types and imaging centers.

Author List

Boxerman JL, Paulson ES, Prah MA, Schmainda KM


Eric Paulson PhD Associate Professor in the Radiation Oncology department at Medical College of Wisconsin
Kathleen M. Schmainda PhD Professor in the Biophysics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Brain Neoplasms
Cohort Studies
Contrast Media
Gadolinium DTPA
Image Enhancement
Injections, Intravenous
Magnetic Resonance Imaging
Middle Aged
Neoplasm Recurrence, Local
Retrospective Studies
Young Adult