Faculty Collaboration Database

The effect of pulse sequence parameters and contrast agent dose on percentage signal recovery in DSC-MRI: implications for clinical applications. AJNR Am J Neuroradiol 2013 Jul;34(7):1364-9

Date

02/16/2013

Pubmed ID

23413249

Pubmed Central ID

PMC4316677

DOI

10.3174/ajnr.A3477

Scopus ID

2-s2.0-84880846810 (requires institutional sign-in at Scopus site)   32 Citations

Abstract

BACKGROUND AND PURPOSE: Both technical and pathophysiologic factors affect PSR in DSC-MR imaging. We aimed to determine how TE, flip angle (α), and contrast dose impact PSR in high-grade gliomas.

MATERIALS AND METHODS: We retrospectively computed PSR maps for 22 patients with high-grade gliomas, comparing 3 DSC-MR imaging methods by using single-dose gadodiamide without preload administration: A (n = 7), α = 35°, TE = 54 ms; B (n = 5), α = 72°, TE = 30 ms; C (n = 10), α = 90°, TE = 30 ms. Methods A-C served as preload for subsequent dynamic imaging using method D (method C parameters but with double-dose contrast). We compared first- and second-injection tumor PSR for methods C and D (paired t test) and tumor PSR for both injections grouped by the first-injection acquisition method (3-group nonparametric 1-way ANOVA). We compared PSR in tumor and normal brain for each first- and second-injection method group (paired t test).

RESULTS: First-injection PSR in tumor and normal brain differed significantly for methods B (P = .01) and C (P = .05), but not A (P = .71). First-injection tumor PSR increased with T1 weighting with a significant main effect of method groupings (P = .0012), but there was no significant main effect for first-injection normal brain (P = .93), or second-injection tumor (P = .95) or normal brain (P = .13). In patients scanned with methods C and D, first-injection PSR significantly exceeded second-injection PSR for tumor (P = .037) and normal brain (P < .001).

CONCLUSIONS: PSR strongly depends on the T1 weighting of DSC-MR imaging, including pulse sequence (TE, α) and contrast agent (dose, preload) parameters, with implications for protocol design and the interpretation and comparison of PSR values across tumor types and imaging centers.

Author List

Boxerman JL, Paulson ES, Prah MA, Schmainda KM

Authors

Eric Paulson PhD Chief, Professor in the Radiation Oncology department at Medical College of Wisconsin
Kathleen M. Schmainda PhD Professor in the Biophysics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Aged
Algorithms
Astrocytoma
Brain
Brain Neoplasms
Cohort Studies
Contrast Media
Female
Gadolinium DTPA
Glioblastoma
Glioma
Humans
Image Enhancement
Injections, Intravenous
Magnetic Resonance Imaging
Male
Middle Aged
Neoplasm Recurrence, Local
Oligodendroglioma
Retrospective Studies
Young Adult