Faculty Collaboration Database

Management of primary hepatopancreatobiliary small cell carcinoma. J Surg Oncol 2013 Jun;107(7):692-5

Date

01/03/2013

Pubmed ID

23280574

DOI

10.1002/jso.23305

Scopus ID

2-s2.0-84878298180 (requires institutional sign-in at Scopus site)   10 Citations

Abstract

BACKGROUND AND OBJECTIVES: Primary small cell carcinomas (SCC) of the pancreas, liver, gallbladder, and bile ducts have only been described in case reports. We hypothesized that surgical treatment was associated with improved overall survival (OS) for patients with localized hepatopancreatobiliary SCC.

METHODS: The Surveillance, Epidemiology, and End-Results (SEER) database was queried for patients with SCC from 1998 to 2008. Survival was analyzed with Cox proportional hazards models.

RESULTS: Eighty-five patients had nonmetastatic hepatopancreatobiliary SCC and operative treatment data. Hepatic SCC was associated with a 2 month median OS, and no patient underwent surgery. Stage-adjusted median OS for pancreatobiliary SCC patients undergoing resection (19 months, 95% confidence interval [CI]: 10-42 months) was greater than those who were not resected (8 months, 95% CI: 4-12 months, P = 0.0052). Both surgical resection (hazard ratio [HR]: 0.42, 95% CI: 0.29-0.63, P < 0.001) and administration of radiation therapy (HR: 0.50, 95% CI: 0.35-0.71, P < 0.001) independently predicted prolonged OS in adjusted models.

CONCLUSION: Surgical resection was associated with prolonged survival for patients with localized pancreatic, gallbladder, and biliary primaries. While we recognize several biases inherent in a population-based study, these results provide insight into the survival that can be achieved with surgical resection of SCC in these specific locations.

Author List

Groeschl RT, Christians KK, Turaga KK, Gamblin TC

Authors

Kathleen K. Christians MD Professor in the Surgery department at Medical College of Wisconsin
Thomas Clark Gamblin MD Professor in the Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Aged
Biliary Tract Neoplasms
Carcinoma, Small Cell
Female
Humans
Liver Neoplasms
Male
Middle Aged
Odds Ratio
Pancreatic Neoplasms
Patient Selection
Proportional Hazards Models
Retrospective Studies
SEER Program
Selection Bias
Survival Analysis
Treatment Outcome
United States