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Splenic rupture in a parental donor undergoing peripheral blood progenitor cell mobilization. J Pediatr Hematol Oncol 2004 Nov;26(11):761-3

Date

11/16/2004

Pubmed ID

15543014

DOI

10.1097/00043426-200411000-00015

Scopus ID

2-s2.0-9644265310   37 Citations

Abstract

Peripheral blood progenitor cells (PBPCs) are now widely used as a source of progenitor cells for allogeneic transplantation. Recombinant human granulocyte colony-stimulating factor is used to mobilize PBPCs for collection by leukapheresis. Although side effects of mobilization are generally benign, adverse effects have been reported. The authors present a case of spontaneous splenic rupture, without splenomegaly, in a parental donor undergoing PBPC mobilization, review the literature regarding this adverse event, and explore issues regarding donor safety.

Author List

Dincer AP, Gottschall J, Margolis DA

Author

David A. Margolis MD Interim Chair, Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adult
Granulocyte Colony-Stimulating Factor
Hematopoietic Stem Cell Mobilization
Humans
Male
Parents
Peripheral Blood Stem Cell Transplantation
Spleen
Splenic Rupture
Tissue Donors