Splenic rupture in a parental donor undergoing peripheral blood progenitor cell mobilization. J Pediatr Hematol Oncol 2004 Nov;26(11):761-3
Date
11/16/2004Pubmed ID
15543014DOI
10.1097/00043426-200411000-00015Scopus ID
2-s2.0-9644265310 (requires institutional sign-in at Scopus site) 37 CitationsAbstract
Peripheral blood progenitor cells (PBPCs) are now widely used as a source of progenitor cells for allogeneic transplantation. Recombinant human granulocyte colony-stimulating factor is used to mobilize PBPCs for collection by leukapheresis. Although side effects of mobilization are generally benign, adverse effects have been reported. The authors present a case of spontaneous splenic rupture, without splenomegaly, in a parental donor undergoing PBPC mobilization, review the literature regarding this adverse event, and explore issues regarding donor safety.
Author List
Dincer AP, Gottschall J, Margolis DAAuthor
David A. Margolis MD Chair, Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultGranulocyte Colony-Stimulating Factor
Hematopoietic Stem Cell Mobilization
Humans
Male
Parents
Peripheral Blood Stem Cell Transplantation
Spleen
Splenic Rupture
Tissue Donors