Faculty Collaboration Database

Effects of subdural application of lidocaine in patients with focal epilepsy. Epilepsy Res 2008 Feb;78(2-3):235-9

Date

01/08/2008

Pubmed ID

18178061

DOI

10.1016/j.eplepsyres.2007.11.007

Scopus ID

2-s2.0-38549122476 (requires institutional sign-in at Scopus site)   14 Citations

Abstract

Antiepileptic drug (AED) delivery directly into the neocortex has recently been shown to be able to both prevent and terminate focal seizures in rats. The present clinical experiment aimed to test the local effects of lidocaine delivered onto the pia mater adjacent to epileptogenic zones in human patients. Administration of lidocaine resulted in a marked diminishment of spike counts on all patients, with a decremental effect of lidocaine on the faster frequency elements of individual spikes and overall testing epochs. The direct cortical application of lidocaine appears to affect local epileptogenic activity in human patients with intractable focal epilepsy.

Author List

Madhavan D, Mirowski P, Ludvig N, Carlson C, Doyle W, Devinsky O, Kuzniecky R

Author

Chad Carlson MD Professor in the Neurology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Anesthetics, Local
Anticonvulsants
Drug Resistance
Dura Mater
Electroencephalography
Epilepsies, Partial
Female
Humans
Injections
Intracranial Arteriovenous Malformations
Lidocaine
Male
Neurosurgical Procedures