Faculty Collaboration Database

Cardiac plasma cell granulomas: response to oral steroid treatment. Pediatr Cardiol 2004;25(4):406-10

Date

04/01/2004

Pubmed ID

15054564

DOI

10.1007/s00246-003-0269-x

Scopus ID

2-s2.0-3342936386 (requires institutional sign-in at Scopus site)   17 Citations

Abstract

Plasma cell granulomas are lesions of uncertain histogenesis arising in a variety of locations, most commonly the lung. Treatment for these lesions is complete surgical excision if possible. Unresectable pulmonary lesions respond to oral corticosteroids and radiation therapy. We report the long-term outcome of two unusual pediatric cases of cardiac plasma cell granulomas originating within the right ventricle and posterior aspect of the left ventricle. The limited literature reports advocate surgical resection for this entity, with no discussion of alternative treatment strategies for unresectable lesions. We prospectively evaluated the response to postoperative oral steroid therapy, as complete surgical excision was not possible in either case. Sequential echocardiography demonstrated additional significant reduction in the size of the masses and the patients remain asymptomatic at 9 and 5.5 years follow-up, without evidence of obstruction or recurrence. Oral corticosteroids should be considered as a treatment option for any unresectable plasma cell granuloma.

Author List

Ferbend P, Abramson LP, Backer CL, Mavroudis C, Webb CL, Doll JA, Junewick JJ, Crawford SE

Author

Jennifer A. Doll PhD Assistant Professor in the Biomedical Sciences department at University of Wisconsin - Milwaukee

MESH terms used to index this publication - Major topics in bold

Administration, Oral
Biopsy
Cardiac Surgical Procedures
Echocardiography
Female
Follow-Up Studies
Glucocorticoids
Granuloma, Plasma Cell
Heart Ventricles
Humans
Infant
Magnetic Resonance Imaging
Male
Microscopy, Electron
Prednisone
Prospective Studies
Treatment Outcome