Haematogones in the peripheral blood of adults: a four-colour flow cytometry study of 102 patients. Br J Haematol 2004 Jul;126(2):209-12
Date
07/09/2004Pubmed ID
15238141DOI
10.1111/j.1365-2141.2004.05011.xScopus ID
2-s2.0-3242659839 (requires institutional sign-in at Scopus site) 23 CitationsAbstract
Haematogones have been extensively characterized in bone marrow, but not in the peripheral blood (PB). We studied 102 PB samples from adult patients with a sensitive flow cytometry method. Sixty-six of 102 samples (65%) contained detectable haematogones, ranging from 0.01% to 1.3% of white blood cells (median 0.06%, mean 0.13%). Of 66 cases with complete blood count data, 51 had absolute haematogone counts of 0.00037-0.105 x 10(9)/l (median 0.0054 x 10(9)/l, mean 0.012 x 10(9)/l). PB haematogones belonged exclusively to the most mature maturational stage. These findings have implications for PB analysis of minimal residual disease in acute lymphoblastic leukaemia and follicular lymphoma.
Author List
Kroft SH, Asplund SL, McKenna RW, Karandikar NJAuthor
Steven Howard Kroft MD Chair, Professor in the Pathology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAged
Aged, 80 and over
Antigens, CD20
B-Lymphocytes
Blood Cell Count
Case-Control Studies
Female
Flow Cytometry
Humans
Leukemia, Lymphocytic, Chronic, B-Cell
Leukocyte Count
Lymphoma, Follicular
Male
Middle Aged
Neoplasm, Residual
Neprilysin
Stem Cells
